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This study was performed to evaluate the acute oral toxicity of an oriental medical prescription for obesity treatment, SH21-B, in Sprague-Dawley rats and Beagle dogs. SH21-B was administered in rats at does of 0㎎/㎏, 2,000㎎/㎏, and 5,000㎎/㎏. And also SH21-B was administered in Beagle dogs at does of150㎎/㎏, 300㎎/㎏, and 600㎎/㎏. The rats and dogs of both sexes were observed daily for 14 days after single oral administration. Two female rats, one administered at 2,000㎎/㎏ and the other administered at 5,000㎎/㎏, died, but no dead animal was observed among male rats. Therefore LD50 in the female rat is observed to be 8,710㎎/㎏, and MLD(Minimum Lethal Dose) of the male rat is observed to be more than 5,000㎎/㎏ Among dogs, no dead animal was observed up to 600㎎/kg and MLD is observed to be more than 600㎎/㎏.
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